Basic Info.
Model NO.
951-77-9
EINECS
213-454-1
Type
Pharmaceutical Intermediates
Appearance
Powder
Quality
Refined
Colour
White
Sample
Available
MOQ
1kg
Storage
Cool Dry Place
Self-Life
3 Years
Transport Package
Drum
Specification
Powder
Trademark
Labeyond
Origin
China
Production Capacity
10mt/Month
Product Description
2'-Deoxycytidine is a deoxyribonucleoside, a component of deoxyribonucleic acid. It can also be used as a precursor for 5-aza-2′-deoxycytidine, a treatment for MDS patients. This compound slows the cell cycle by interfering with the methylation of the P15/INK4B gene, increasing the expression of P15/INK4B protein which subdues the transformation of MDS to leukemia.
Deoxycytidine can also serve as a biomarker for tumor diagnosis. Deoxycytidine can be used as a biomarker for breast cancer patients and healthy individuals. 5-(Hydroxymethyl)-2′-deoxycytidine (5-hmdC), 5-(formyl)-2′-deoxycytidine (5-fodC), and 5-(carboxyl)-2′-deoxycytidine (5-cadC) are intermediates in the DNA demethylation pathway and can act as biomarkers. 5-hmdC levels were significantly reduced in urine samples of breast cancer patients, while 5-fodC and 5-cadC levels were elevated.
2'-Deoxycytidine is a very important pharma intermediate.
Deoxycytidine can also serve as a biomarker for tumor diagnosis. Deoxycytidine can be used as a biomarker for breast cancer patients and healthy individuals. 5-(Hydroxymethyl)-2′-deoxycytidine (5-hmdC), 5-(formyl)-2′-deoxycytidine (5-fodC), and 5-(carboxyl)-2′-deoxycytidine (5-cadC) are intermediates in the DNA demethylation pathway and can act as biomarkers. 5-hmdC levels were significantly reduced in urine samples of breast cancer patients, while 5-fodC and 5-cadC levels were elevated.
2'-Deoxycytidine is a very important pharma intermediate.
| Test Items | Acceptance criteria | Results |
| Appearance | White to off-white powder | White powder |
| Identification (HPLC) | The retention time of the major peak from the Sample solution corresponds to that of the Standard solution, as obtained in the Assay. | Complies |
| Water Content% (K.F.) | ≤1.0% | 0.3% |
| Specific Rotation (10mg/ml, HO) | +56.0°~+61.0° | +59.1° |
| Related substance (HPLC) | Any individual unspecified impurity≤0.5% (275nm) | 0.4% |
| Purity (HPLC) | ≥99.0% (275nm) | 99.6% |
| Assay (on anhydrous basis) | 98.0%~102.0% | 100.2% |
